Glutathione For Skin – Glutathione Film

Are you taking Glutathione daily? In Korea, glutathione consumption rapidly grows as a skin-lightening agent, promoting even skin tone and improving the look of discoloration as well as anti-aging properties – Glutathione also has many health benefits however the popularity boomed last couple of years as an essential ‘Skincare Assistance’ 😋. I will talk more about the potential skin benefits of glutathione and may help you choose among the large number of products that are produced in Korea.

💊What is Glutathione?

Glutathione is a powerful antioxidant that is produced naturally in the body and plays an important role in various physiological functions. It is also a peptide (tripeptide) composed of three amino acids: cystine, glutamic acid and glycine.

💊Benefits of Glutathione

• Antioxidant – combat free radicals
• Promotes liver health and detoxify the body
• Anti-inflammatory effects
• Support immune system
• Whitening (inhibit the production of melanin)
• Improve skin firmness and elasticity

👉Glutathione’s antioxidant properties contribute to premature aging and may help reduce inflammation and promote healing, potentially leading to clear acne & blemishes. It also helps to inhibit the production of melanin – inhibits tyrosinase activity and switches from Eumelanin to Pheomelanin production – which can lead to a more even skin tone and reduce the appearance of dark spots and hyperpigmentation.

💊Glutathione Type

In the human body, glutathione exists in two states, reduced (GSH) and oxidized (GSSG), which can be readily converted to each other (interchangeable).

• Oxidized Glutathione
• Reduced Glutathione or L-Glutathione

cf. Acetyl-Glutathione (acetylated form, N- and S-Acetyl form) is a derivative of L-glutathione (non-acetylated form) and more reliable in the blood (3~4 times higher bioavailability), the compound protected from oxidation in the digestive tract – more stable, better absorption.

👉 L-glutathione VS Glutathione?
In most cases, when people refer to glutathione supplements or products, they are referring to L-glutathione, as this is the form that is naturally produced in the human body and used for its various functions, so it’s important to ensure that they are in the L-glutathione (reduced) form, as this is the form that the body can readily utilize. Liposomal glutathione supplements are also a good option, as they help to improve absorption.

💊 Glutathione Supplements Common Forms

1. Oral Glutathione
   :Taking glutathione orally, such as in the form of capsules or tablets. The absorption can be limited as it can be broken down in the stomach before it reaches the bloodstream.
2. Liposomal Glutathione
   :Encapsulating glutathione in tiny lipid (fat) particles, which can help protect it from degradation in the digestive tract and improve its absorption. Liposomal glutathione is believed to have higher bioavailability compared to standard oral supplements.
3. Sublingual Glutathione
   : The form of liquid or lozenges that are placed under the tongue. Can be absorbed directly into the bloodstream through the thin mucous membranes in the mouth, bypassing the digestive system.
4. Intravenous (IV) Glutathione
   : Administering glutathione directly into the bloodstream through an IV injection, however, it requires medical supervision and is not suitable for routine supplementation.
5. Topical Glutathione
   : Some skincare products contain glutathione in topical formulations. While this may have localized benefits for the skin, it may not significantly increase systemic glutathione levels in the body.

cf. Trizomal™ Glutathione: advanced formula that gives the body three ways to increase and optimize glutathione levels. It not only includes bioactive glutathione (GSH, reduced form) but also S-acetyl glutathione and N-acetyl cysteine – I haven’t found clinical support yet from the internet so am just mentioning the type of form that exists 😅.

👉The effectiveness of glutathione absorption can depend on various factors, including the formulation and delivery method. Additional factors such as the individual’s digestive health and metabolism can influence absorption, too.

💊What is Glutathione Film?

A thin film type glutathione supplement (ODF, Oral Dissolving Film) that is attached on your palate of the mouth and is directly absorbed into your blood vessel without going through the digestive system – similar to Sublingual Glutathione type.

💊Product Recommendations

👉How to calculate Glutathione content per film (sheet)?
Film weight x Glutathione(Enzyme) Content(%) x Glutathione purity(%)
Ex) 325mg (film weight) x 30.77% (glutathione) x 50% (purity) = 50mg (glutathione)

1. Esther Formula Glutathione Direct Film 5X

• Glutathione content (75mg), 75% highest purity glutathione from Netherlands
• Formulated with Vitamin C, milk thistle, L-cysteine and Vitamin E
  (₩67,000 – Sale Price ₩49,000 korean won)

cf. Esther Formula Glutathione Direct Film 3X contains glutathione (50mg) and formulated with Vitamin C, milk thistle, L-cysteine & Vitamin E: Esther Formula film is the first film-type glutathione produced in Korea and over 2 million sold.

2. InnerB Glutathione White Film

• Glutathione content (65mg), 50% highest purity glutathione from Canada
• Formulated with milk thistle, L-cysteine, Vitamin C & E, Vitamin B2, B6, B12 and Selenium
• Contains Collagen, Elastin, Hyaluronic Acid, Niacin
  (₩41,000 – Sale Price ₩29,000 )

3. BB LAB Glutathione White Film

• Glutathione content (65mg), 50% highest purity glutathione from China
• Formulated with milk thistle, L-cysteine, Vitamin C and Vitamin E
• Contains Collagen, Elastin, Hyaluronic Acid
  (₩56,900 – Sale Price ₩29,000)

4. Dr.Fill Brightening Glutathione Film

• Glutathione content (65mg), 50% highest purity glutathione from Canada
• Formulated with milk thistle, L-cysteine, Vitamin C, Vitamin E and Selenium
• Contains Fish Collagen, Elastin, Hyaluronic Acid
  (₩64,000 – Sale Price ₩36,000)

5. Nutricore WCS Max Glutathione Film

• Glutathione content (65mg), 50% highest purity glutathione from India
• Formulated with milk thistle, L-cysteine, Vitamin C, Vitamin B2, B6, B12 and Selenium
• Contains Niacin, Fish Collagen, Elastin, Hyaluronic Acid, Ceramide
  (₩333,000 – Sale Price ₩49,000)

6. Dr.Lean Super Glutathione Film

• Glutathione content (65mg), 50% highest purity glutathione from India
• Formulated with milk thistle, L-cysteine, Vitamin C, Vitamin B2, B6, B12 and Selenium
• Contains Collagen, Elastin, Hyaluronic Acid, Nicotinamide
  (₩55,000)

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👉Dr.Lean and Nutricore have just released upgrade version – purity 98%, and the glutathione contents and prices are:

• Dr.Lean Super Glutathione Max Film (127mg/film, ₩74,500)
• Nutricore WCS Max Glutathione Film (120mg/film, ₩79,000 sale price)

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💊Recommended Dosage

The recommended daily dose of glutathione for adults ranges from 500±mg per day and it’s important to know that oral administered GSH has low bioavailability (less than 10%) because it is broken down in the gut into the amino acids so compared to this, film type of glutathione contains 50~65mg is appropriate, and also can take up to 2 films per day.

👉Glutathione Dosage

• The European Journal of Nutrition found that daily consumption of 500-1,000mg of glutathione supplements can be effective at increasing the storage of GSH.
• Several studies indicate positive results with dosages between 250-300mg daily, but higher therapeutic doses may be necessary in some cases
• Dose range 250 mg orally for daily maintenance of GSH levels – has appeared on several sites
• A typical recommended dose of oral glutathione is ranges from 50 mg (and higher) per day
  etc,. daily recommendation dosage has lots of opinion 🤔

💊Conclusion

Glutathione is naturally manufactured in the human body, however that natural glutathione is jeopardized by numerous factors, including stress, pollutants and individual health conditions. Also, study showed that daily consumption of Glutathione (GSH) supplements was effective at increasing body compartment stores of GSH, so it is better taken daily not only for skin but general health.

The effectiveness and additional product recommendations both overseas brand and Korean manufactured will be mentioned on next post so keep an eye on my post 😊

Thanks for reading~

*Some articles quoted from Google, including the National Institutes of Health site and the product comparisons are made by myself based on popularity and brand trust.